FRIDAY, Feb. 5 (HealthDay News) -- Secretion of the hormone adiponectin from adipocytes in response to cytokines or adipose tissue macrophages is suppressed in women with polycystic ovary syndrome (PCOS), according to a study in the February issue of the Journal of Clinical Endocrinology & Metabolism.
Gregorio Chazenbalk, Ph.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues measured adiponectin secretion by isolated adipocytes in response to various cytokines and in adipocytes cocultured with adipose tissue macrophages from overweight and obese women with PCOS and a control group of healthy women.
After treatment with interleukin-6, monocyte chemoattractant protein-1, or tumor necrosis factor-α, the researchers found that adiponectin secretion decreased in isolated adipocytes from PCOS patients and increased in isolated adipocytes from healthy women, although the difference was only significant for tumor necrosis factor-α. Coculture of adipocytes with adipose tissue macrophages was also associated with a significant decrease in adiponectin secretion from adipocytes from PCOS patients but not healthy women.
"Our results suggest that adiponectin secretion by adipocytes in response to cytokines/chemokines and most notably in response to coculturing with adipose tissue macrophages differs between PCOS and control women, favoring greater suppression of adiponectin in PCOS," Chazenbalk and colleagues conclude.
One author reported receiving consulting fees from Bionovo and Merck.
